PENNSAID 2%: Get relief where the pain is

Osteoarthritis (OA) can cause the pain you feel in your knee. PENNSAID 2% is targeted pain relief  it’s a topical solution that you apply directly to your knee.


PENNSAID 2% is a topical, nonsteroidal anti-inflammatory drug, or NSAID for short. All NSAIDs — including pills, gels, creams, and over-the-counter medicines like ibuprofen and naproxen — have a risk of serious cardiovascular (heart) and gastrointestinal (stomach) side effects.


Ask your doctor if PENNSAID 2% is right for you.

Pay as little as $0 with the PENNSAID 2% co-pay card

Save money every time you fill your eligible PENNSAID 2% prescription*

*Terms and Conditions: Offer cannot be combined with any other rebate or coupon, free trial, or similar offer for the specified prescription. Not valid for prescriptions reimbursed in whole or in part by Medicaid, Medicare, VA, DOD, TriCare, or other federal or state programs (including state prescription drug programs). Offer good only in the United States at participating retail pharmacies for eligible Horizon products. Offer not valid where otherwise prohibited by law, for example by applicable state law prohibiting co-pay cards. Absent a change in Massachusetts law, offer not valid in Massachusetts after January 1, 2020. Horizon reserves the right to rescind, revoke, or amend the offer without notice. The selling, purchasing, trading, or counterfeiting of this offer is prohibited by law. This card is not insurance and is not intended to substitute for insurance. Participating patients and pharmacists understand and agree to comply with all Terms and Conditions of this offer. Patients must be 18 or older.


It's easy to apply PENNSAID 2%

See how to apply PENNSAID 2% directly to the knee

Apply PENNSAID 2% twice a day directly to the knee

PENNSAID 2% is easy to use. Apply two times a day to the front, back, and sides of the knee. The PENNSAID 2% pump gives you the recommended dose of 40 mg (2 pumps) each time you use it.

There’s no messy measuring or complicated dosing.

How to prepare the PENNSAID 2% pump

Before you use PENNSAID 2% for the first time, you need to prepare the pump. Push the pump down fully 4 times to prepare it. Throw away any liquid that comes out when you do this. This will ensure that you get the correct amount the first time you use PENNSAID 2%. Your new PENNSAID 2% pump is now ready to use as directed.

How to apply PENNSAID 2%

  1. Wash your hands with soap and water before and after applying PENNSAID 2%.
  2. Remove the bottle cap and press the pump head down firmly and fully to dispense PENNSAID 2% into the palm of your hand. Release the pump head. Then press the pump head down firmly and fully a second time. Put 2 pumps of PENNSAID 2% either on your hand or directly on your knee. When you use PENNSAID 2%, you can hold the bottle
    at an angle.
  3. Apply on clean, dry skin without cuts, infections or rashes.
  4. Spread PENNSAID 2% evenly on all sides of your painful knee. If both knees have OA, then repeat on the other knee.
  5. Allow the treated area to dry before covering.

Do not get PENNSAID 2% in or near your eyes, nose, and mouth. If you get PENNSAID 2% in your eyes, rinse your eyes right away with water or saline. Use PENNSAID 2% only twice daily as prescribed.


  • Wash and dry hands after use.
  • Protect knees from natural and artificial sunlight.
  • Do not apply to open wounds.
  • Avoid contact with eyes, nose, and mouth.
  • Wait until area is dry to cover with clothing or apply sunscreen, insect repellent, cosmetics, topical medications, or other substances.
  • Avoid using dressings that seal a wound.
  • Do not apply external heat.
  • Avoid exercise after application of PENNSAID 2%.

Indication, Usage, and Important Safety Information



What is PENNSAID® (diclofenac sodium topical solution) 2% w/w?

PENNSAID® (diclofenac sodium topical solution) 2% w/w is a nonsteroidal anti-inflammatory drug (NSAID) applied to the skin, used for treating the pain of osteoarthritis of the knee(s).



What is the most important information I should know about PENNSAID?

  • NSAIDs can cause an increased risk of a heart attack or stroke that can lead to death. This risk may occur early in treatment and may increase with longer use and with increasing doses.
  • NSAIDs can cause an increased risk of bleeding, ulcers, and tears (perforation) of the esophagus, stomach and intestines. These events can occur at any time during use, without warning symptoms and may cause death. Elderly patients and patients with a history of ulcer disease or stomach or intestine bleeding are at greater risk for getting an ulcer or bleeding.
  • You should take PENNSAID exactly as prescribed, at the lowest dose possible and for the shortest time needed.


PENNSAID can cause serious side effects. Stop taking PENNSAID and call your doctor or go to your emergency department right away if you get:

  • Difficulty breathing, swelling of the face or throat. These could be signs of a serious allergic reaction.
  • Chest pain, shortness of breath, weakness in one part or side of your body, or slurring of speech. These could be signs of a serious blood clotting event.
  • Upper stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of an esophagus, stomach, or intestinal ulcer, bleed, or tear. Note: if you are also taking low-dose aspirin, you are at increased risk for esophagus, stomach, or intestinal bleeding.
  • Nausea, more tired or weaker than usual, itching, yellowing of the skin or eyes, right upper abdomen tenderness, and “flu-like” symptoms. These could be signs of a liver problem.
  • Shortness of breath, unexplained weight gain, or swelling of the arms, legs, hands or feet. These could be signs of a serious heart problem.
  • Any type of rash. This could be a sign of a serious skin reaction.

These are not all of the possible side effects of PENNSAID. Please talk to your doctor if you experience any symptoms that bother you or that do not go away.


Who should not use PENNSAID?

  • are in the hospital for a certain heart surgery called coronary artery bypass graft surgery.
  • know you are allergic to diclofenac or any other ingredient of PENNSAID.
  • have experienced asthma, hives, or allergic-type reactions after taking aspirin or other NSAIDs. Serious allergic reactions to NSAIDs, including death, have been reported in such patients.



How should I use PENNSAID?

PENNSAID is applied directly to the front, back, and sides of your knee(s). Avoid contact of PENNSAID with the eyes, nose, and mouth. If eye contact occurs, immediately wash out the eye with water and contact your health care provider if irritation persists for more than an hour. Avoid skin-to-skin contact between other people and the knee(s) to which PENNSAID was applied until the knee(s) is completely dry. DO NOT apply PENNSAID to open wounds, infections, or rashes.  DO NOT shower for at least 30 minutes after applying PENNSAID or wear clothing over the PENNSAID treated knee(s) until the treated knee(s) is dry. DO wash and dry hands before and after use, protect your treated knee(s) from natural or artificial sunlight, and wait until the treated knee(s) is completely dry before applying sunscreen, insect repellant, lotion, moisturizer, cosmetics, or other topical medication.


What are the possible side effects of PENNSAID?

The most common side effects of PENNSAID are application site reactions, such as dryness, peeling, redness, itching, pain, skin hardening, rash, blisters, and scabbing. Other side effects are bladder infection, bruising, sinus congestion, nausea, upset stomach, stomach pain, gas, constipation, and diarrhea.


What other medications might interact with PENNSAID?

Avoid using PENNSAID while taking other NSAIDs unless your doctor says it is OK. NSAIDs may be present in over-the-counter medications for treatment of colds, fever, or insomnia; refer to the label of over-the-counter medications you are taking or ask your pharmacist. Do not use PENNSAID and low-dose aspirin until you talk to your health care provider. Tell your doctor about all of the medicines you take as some medicines can react with NSAIDs and cause serious side effects.


What should I tell my health care provider?

Before starting PENNSAID, tell your health care provider if you have a history of ulcer disease or esophagus, stomach, or intestine bleeding, liver or kidney problems, high blood pressure, asthma, or are pregnant, trying to become pregnant, or breast feeding. Also tell your doctor about all of the medicines you take, including prescription or over-the-counter medicines, vitamins, or herbal supplements. Do not start taking new medicines without talking to your health care provider first.


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088. You may also contact the Horizon Therapeutics Medical Information Department toll-free at 1-866-479-6742 or


The risk information provided here is not comprehensive. To learn more, talk about PENNSAID 2% with your health care provider or pharmacist. Click here for the Full Prescribing Information and Medication Guide or call 1-866-479-6742.