Image of a woman holding the PENNSAID 2% pump bottle, pressing down on the pump, the other hand is cupped beneath to receive the PENNSAID 2% Three photos of application to the front, sides, and back of knee

See how easy it is to apply PENNSAID® 2%


  • Unlike other topical diclofenac sodium products on the market, which are used 4 times a day,3,4 twice-daily PENNSAID is used with a convenient metered-dose pump.1
  • The precise metered-dose pump for twice-daily PENNSAID 2% gives an accurate amount (20 mg of diclofenac per pump use) each time.1

Preparing the PENNSAID 2% pump

Before using PENNSAID 2% for the first time, prime the pump by pushing down fully 4 times. Discard any solution that is expelled to ensure an accurate dose is delivered the first time you use PENNSAID 2%. Your new PENNSAID 2% pump is now ready to use as directed.1

Application instructions1

  1. Wash hands with soap and water before and after applying PENNSAID 2%.
  2. Remove the bottle cap and press the pump head down firmly and fully to dispense PENNSAID 2% into the palm of your hand. Release the pump head. Then press the pump head down firmly and fully a second time. Put 2 pumps of PENNSAID 2% either on your hand or directly on your knee. When you use PENNSAID 2%, you can hold the bottle at an angle.
  3. Apply on clean, dry skin without cuts, infections, or rashes.
  4. Spread evenly on all sides of affected knee. If both knees are affected, repeat on the other knee.
  5. Allow treated area to dry before covering.
  6. Avoid contact with eyes, nose, and mouth. If you get PENNSAID 2% in your eyes, rinse your eyes right away with water or saline. Call your doctor if irritation persists for more than an hour.
  7. Use PENNSAID 2% only twice daily as prescribed.

SELECT IMPORTANT SAFETY INFORMATION

  • Wash and dry hands after use.
  • Protect knees from natural and artificial sunlight.
  • Do not apply to open wounds.
  • Avoid contact with eyes, nose, and mouth.
  • Wait until area is dry to cover with clothing or apply sunscreen, insect repellent, cosmetics, topical medications, or other substances.
  • Avoid using dressings that seal a wound.
  • Do not apply external heat.
  • Avoid exercise after application of PENNSAID.

INDICATION AND USAGE

What is PENNSAID® (diclofenac sodium topical solution) 2% w/w?

PENNSAID® (diclofenac sodium topical solution) 2% w/w is a nonsteroidal anti-inflammatory drug (NSAID) applied to the skin, used for treating the pain of osteoarthritis of the knee(s).

IMPORTANT SAFETY INFORMATION

PENNSAID can cause serious side effects. Stop taking PENNSAID and call your doctor or go to your emergency department right away if you get:

These are not all of the possible side effects of PENNSAID. Please talk to your doctor if you experience any symptoms that bother you or that do not go away.

What is the most important information I should know about PENNSAID?

Who should not use PENNSAID?

How should I use PENNSAID?

PENNSAID is applied directly to the front, back, and sides of your knee(s). Avoid contact of PENNSAID with the eyes, nose and mouth. If eye contact occurs, immediately wash out the eye with water and contact your health care provider if irritation persists for more than an hour. Avoid skin-to-skin contact between other people and the knee(s) to which PENNSAID was applied until the knee(s) is completely dry. DO NOT apply PENNSAID to open wounds, infections or rashes, shower for at least 30 minutes after applying PENNSAID or wear clothing over the PENNSAID treated knee(s) until the treated knee(s) is dry. DO wash and dry hands before and after use, protect your treated knee(s) from natural or artificial sunlight, and wait until the treated knee(s) is completely dry before applying sunscreen, insect repellant, lotion, moisturizer, cosmetics, or other topical medication.

What are the possible side effects of PENNSAID?

The most common side effects of PENNSAID are application site reactions, such as dryness, peeling, redness, itching, pain, skin hardening, rash, blisters, and scabbing. Other side effects are bladder infection, bruising, sinus congestion, nausea, upset stomach, stomach pain, gas, constipation, and diarrhea.

What other medications might interact with PENNSAID?

Avoid using PENNSAID while taking other NSAIDs unless your doctor says it is OK. NSAIDs may be present in over-the-counter medications for treatment of colds, fever, or insomnia; refer to the label of over-the-counter medications you are taking or ask your pharmacist. Do not use PENNSAID and low-dose aspirin until you talk to your health care provider. Tell your doctor about all of the medicines you take as some medicines can react with NSAIDs and cause serious side effects.

What should I tell my healthcare provider?

Before starting PENNSAID, tell your health care provider if you have a history of ulcer disease or esophagus, stomach or intestine bleeding, liver or kidney problems, high blood pressure, asthma, or are pregnant, trying to become pregnant or are breast feeding. Also tell your doctor about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. Do not start taking new medicines without talking to your health care provider first.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation@horizonpharma.com.

The risk information provided here is not comprehensive. To learn more, talk about PENNSAID 2% with your healthcare provider or pharmacist. Click here for the Prescribing Information and Medication Guide or call 1-866-479-6742.

SCROLL DOWN FOR COMPLETE BOXED WARNING

WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS
Cardiovascular Thrombotic Events

Gastrointestinal Bleeding, Ulceration, and Perforation

TAP TO CLOSE

INDICATION AND USAGE

What is PENNSAID® (diclofenac sodium topical solution) 2% w/w?

PENNSAID® (diclofenac sodium topical solution) 2% w/w is a nonsteroidal anti-inflammatory drug (NSAID) applied to the skin, used for treating the pain of osteoarthritis of the knee(s).

IMPORTANT SAFETY INFORMATION

PENNSAID can cause serious side effects. Stop taking PENNSAID and call your doctor or go to your emergency department right away if you get:

These are not all of the possible side effects of PENNSAID. Please talk to your doctor if you experience any symptoms that bother you or that do not go away.

What is the most important information I should know about PENNSAID?

Who should not use PENNSAID?

How should I use PENNSAID?

PENNSAID is applied directly to the front, back, and sides of your knee(s). Avoid contact of PENNSAID with the eyes, nose and mouth. If eye contact occurs, immediately wash out the eye with water and contact your health care provider if irritation persists for more than an hour. Avoid skin-to-skin contact between other people and the knee(s) to which PENNSAID was applied until the knee(s) is completely dry. DO NOT apply PENNSAID to open wounds, infections or rashes, shower for at least 30 minutes after applying PENNSAID or wear clothing over the PENNSAID treated knee(s) until the treated knee(s) is dry. DO wash and dry hands before and after use, protect your treated knee(s) from natural or artificial sunlight, and wait until the treated knee(s) is completely dry before applying sunscreen, insect repellant, lotion, moisturizer, cosmetics, or other topical medication.

What are the possible side effects of PENNSAID?

The most common side effects of PENNSAID are application site reactions, such as dryness, peeling, redness, itching, pain, skin hardening, rash, blisters, and scabbing. Other side effects are bladder infection, bruising, sinus congestion, nausea, upset stomach, stomach pain, gas, constipation, and diarrhea.

What other medications might interact with PENNSAID?

Avoid using PENNSAID while taking other NSAIDs unless your doctor says it is OK. NSAIDs may be present in over-the-counter medications for treatment of colds, fever, or insomnia; refer to the label of over-the-counter medications you are taking or ask your pharmacist. Do not use PENNSAID and low-dose aspirin until you talk to your health care provider. Tell your doctor about all of the medicines you take as some medicines can react with NSAIDs and cause serious side effects.

What should I tell my healthcare provider?

Before starting PENNSAID, tell your health care provider if you have a history of ulcer disease or esophagus, stomach or intestine bleeding, liver or kidney problems, high blood pressure, asthma, or are pregnant, trying to become pregnant or are breast feeding. Also tell your doctor about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. Do not start taking new medicines without talking to your health care provider first.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact the Horizon Pharma Medical Information Department toll-free at 1-866-479-6742 or medicalinformation@horizonpharma.com.

The risk information provided here is not comprehensive. To learn more, talk about PENNSAID 2% with your healthcare provider or pharmacist. Click here for the Prescribing Information and Medication Guide or call 1-866-479-6742.